Analysis of Expression of Myofibroblasts in Oral Submucous Fibrosis: An Immunohistochemistry Study

Background: Oral submucous fibrosis (OSMF) is a chronic disease that produces tissue and considered to be potentially malignant disorder. The exact pathogenesis conversion mechanism of this disorder are still unknown. Myofibroblasts have been implicated as one the possible pathological mechanisms responsible for pathophysiology OSMF. present study was conducted evaluate expression myofibroblasts (MF) in normal mucosa different grades Materials & Methods: sample consisted total 80 specimens. group included specimens from clinically histopathologically confirmed OSMF patients. were divided into four groups. Group 1 19 grade III II had 20 OSMF, 3 with 21 I 4 constituted control epithelium Two sections each all groups obtained. While section stained H E, other immunohistochemically using α-smooth muscle antibody. For analysis, categorized strong, moderate, weak, or absent. All results recorded subjected statistical analysis. Results: In patients, irrespective grade, myofibroblast strong 28.33 percent while it moderate weak 30.00 40.00 respectively. Expression noted significantly increased patients compared controls well (p-value <0.05). Conclusion: raised can also correlated within where advanced stages show comparatively high these smooth muscles like fibroblasts. Hence, we suggest could assessed markers analyzing progression